Make Surgery Hurt Less

With preemptive Caldolor, patients*:

  • Experienced 32% less pain at rest1
  • Experienced 26% less pain with movement1
  • Used 31% less morphine for rescue1

In key clinical trials, the incidence of bleeding, gastric, and renal events was no greater in patients receiving Caldolor compared
to placebo.1,2

Available by Prescription Only
HCPCS code C9279

Important Safety Information

CALDOLOR should be used with caution in patients with congestive heart failure, kidney impairment, at risk of blood clots, and in those who have a history of ulcers or gastrointestinal bleeding. When used in such patients, attention to using the lowest effective dose for the shortest time period is important to reduce the risk of serious adverse events. Ibuprofen has been associated with high blood pressure, serious skin reactions, and serious allergic reactions.

The most common adverse events reported in the controlled clinical trials were nausea, flatulence, vomiting, and headache.

Warning: Risk of Serious Cardiovascular and Gastrointestinal Events

Cardiovascular Risk

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal. Risk may increase with duration of use.
  • CALDOLOR is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Gastrointestinal Risk

  • NSAIDs increase the risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Events can occur at any time without warning symptoms. Elderly patients are at greater risk.

Indications for CALDOLOR

CALDOLOR is indicated in adults for the management of mild to moderate pain, management of moderate to severe pain as an adjunct to opioid analgesics, and reduction of fever.

Caldolor J-Code Now Available

HCPS code J1741 (Please refer to your coding department for complete billing information.)

Please see full Prescribing Information, including Boxed Warning.

*Compared to placebo plus morphine. Results of a multi-center, randomized, double-blind, placebo-controlled trial of patients undergoing total knee or hip replacement, reconstruction, or arthroplasty (N=185). Patients received 800 mg Caldolor or placebo preemptively and every 6 hours after surgery. All patients received intra-operative fentanyl; no other analgesia was given during surgery. Pain was assessed in the immediate post-operative period.


Disclaimer


References:

  1. Singla N, Rock A, Pavliv L. A multi-center, randomized, double-blind placebo-controlled trial of intravenous-ibuprofen
    (IV-ibuprofen) for treatment of pain in post-operative orthopedic adult patients. Pain Medicine. 2010;11:1284-1293.

  2. Prescribing Information for Caldolor. Cumberland Pharmaceuticals Inc. Nashville, TN.